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fluoroplex tissue bath fluorometry system  (IonOptix)

 
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    Structured Review

    IonOptix fluoroplex tissue bath fluorometry system
    Endosomolytic nanoplex delivery system enhances the delivery of p-HSP20 and inhibition of contraction. Rings of rat aorta were suspended in a <t>FluoroPlex</t> Tissue Bath Fluorometry System that can measure contraction and intracellular calcium concentration simultaneously. Rings were untreated (control), treated with different doses of the p-HSP20 peptide alone (100, 500, and 1000 μM), or peptide-nanoplex formulations (100, 200, and 500 μM), and inhibition of contraction and calcium concentration were measured. (A) Representative tracing showing contraction with PE and inhibition of contraction with p-HSP20 NP. (B) Cumulative data demonstrating enhanced inhibition of contraction with p-HSP20 or p-HSP20 NP. (C) Representative tracing showing inhibition of contraction and intracellular calcium concentration with 500 μM p-HSP20 NP (500 μM polyplex). (D) Cumulative data showing percent inhibition of contraction (force) and intracellular calcium concentration ([Ca2+]i). A fivefold increase in peptide mediated bioactivity was observed when delivered through the endosomolytic NP formulation compared to peptide alone without any change in the [Ca2+]i. *p<0.05, **p<0.001, ****p<0.00001, n = 4–6 (one-way ANOVA). p-HSP20 NP, p-HSP20 nanoplex.
    Fluoroplex Tissue Bath Fluorometry System, supplied by IonOptix, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/fluoroplex tissue bath fluorometry system/product/IonOptix
    Average 90 stars, based on 1 article reviews
    fluoroplex tissue bath fluorometry system - by Bioz Stars, 2026-04
    90/100 stars

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    1) Product Images from "Nanotechnology Enabled Modulation of Signaling Pathways Affects Physiologic Responses in Intact Vascular Tissue"

    Article Title: Nanotechnology Enabled Modulation of Signaling Pathways Affects Physiologic Responses in Intact Vascular Tissue

    Journal: Tissue Engineering. Part A

    doi: 10.1089/ten.tea.2018.0169

    Endosomolytic nanoplex delivery system enhances the delivery of p-HSP20 and inhibition of contraction. Rings of rat aorta were suspended in a FluoroPlex Tissue Bath Fluorometry System that can measure contraction and intracellular calcium concentration simultaneously. Rings were untreated (control), treated with different doses of the p-HSP20 peptide alone (100, 500, and 1000 μM), or peptide-nanoplex formulations (100, 200, and 500 μM), and inhibition of contraction and calcium concentration were measured. (A) Representative tracing showing contraction with PE and inhibition of contraction with p-HSP20 NP. (B) Cumulative data demonstrating enhanced inhibition of contraction with p-HSP20 or p-HSP20 NP. (C) Representative tracing showing inhibition of contraction and intracellular calcium concentration with 500 μM p-HSP20 NP (500 μM polyplex). (D) Cumulative data showing percent inhibition of contraction (force) and intracellular calcium concentration ([Ca2+]i). A fivefold increase in peptide mediated bioactivity was observed when delivered through the endosomolytic NP formulation compared to peptide alone without any change in the [Ca2+]i. *p<0.05, **p<0.001, ****p<0.00001, n = 4–6 (one-way ANOVA). p-HSP20 NP, p-HSP20 nanoplex.
    Figure Legend Snippet: Endosomolytic nanoplex delivery system enhances the delivery of p-HSP20 and inhibition of contraction. Rings of rat aorta were suspended in a FluoroPlex Tissue Bath Fluorometry System that can measure contraction and intracellular calcium concentration simultaneously. Rings were untreated (control), treated with different doses of the p-HSP20 peptide alone (100, 500, and 1000 μM), or peptide-nanoplex formulations (100, 200, and 500 μM), and inhibition of contraction and calcium concentration were measured. (A) Representative tracing showing contraction with PE and inhibition of contraction with p-HSP20 NP. (B) Cumulative data demonstrating enhanced inhibition of contraction with p-HSP20 or p-HSP20 NP. (C) Representative tracing showing inhibition of contraction and intracellular calcium concentration with 500 μM p-HSP20 NP (500 μM polyplex). (D) Cumulative data showing percent inhibition of contraction (force) and intracellular calcium concentration ([Ca2+]i). A fivefold increase in peptide mediated bioactivity was observed when delivered through the endosomolytic NP formulation compared to peptide alone without any change in the [Ca2+]i. *p<0.05, **p<0.001, ****p<0.00001, n = 4–6 (one-way ANOVA). p-HSP20 NP, p-HSP20 nanoplex.

    Techniques Used: Inhibition, Concentration Assay



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    Endosomolytic nanoplex delivery system enhances the delivery of p-HSP20 and inhibition of contraction. Rings of rat aorta were suspended in a <t>FluoroPlex</t> Tissue Bath Fluorometry System that can measure contraction and intracellular calcium concentration simultaneously. Rings were untreated (control), treated with different doses of the p-HSP20 peptide alone (100, 500, and 1000 μM), or peptide-nanoplex formulations (100, 200, and 500 μM), and inhibition of contraction and calcium concentration were measured. (A) Representative tracing showing contraction with PE and inhibition of contraction with p-HSP20 NP. (B) Cumulative data demonstrating enhanced inhibition of contraction with p-HSP20 or p-HSP20 NP. (C) Representative tracing showing inhibition of contraction and intracellular calcium concentration with 500 μM p-HSP20 NP (500 μM polyplex). (D) Cumulative data showing percent inhibition of contraction (force) and intracellular calcium concentration ([Ca2+]i). A fivefold increase in peptide mediated bioactivity was observed when delivered through the endosomolytic NP formulation compared to peptide alone without any change in the [Ca2+]i. *p<0.05, **p<0.001, ****p<0.00001, n = 4–6 (one-way ANOVA). p-HSP20 NP, p-HSP20 nanoplex.
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    Endosomolytic nanoplex delivery system enhances the delivery of p-HSP20 and inhibition of contraction. Rings of rat aorta were suspended in a <t>FluoroPlex</t> Tissue Bath Fluorometry System that can measure contraction and intracellular calcium concentration simultaneously. Rings were untreated (control), treated with different doses of the p-HSP20 peptide alone (100, 500, and 1000 μM), or peptide-nanoplex formulations (100, 200, and 500 μM), and inhibition of contraction and calcium concentration were measured. (A) Representative tracing showing contraction with PE and inhibition of contraction with p-HSP20 NP. (B) Cumulative data demonstrating enhanced inhibition of contraction with p-HSP20 or p-HSP20 NP. (C) Representative tracing showing inhibition of contraction and intracellular calcium concentration with 500 μM p-HSP20 NP (500 μM polyplex). (D) Cumulative data showing percent inhibition of contraction (force) and intracellular calcium concentration ([Ca2+]i). A fivefold increase in peptide mediated bioactivity was observed when delivered through the endosomolytic NP formulation compared to peptide alone without any change in the [Ca2+]i. *p<0.05, **p<0.001, ****p<0.00001, n = 4–6 (one-way ANOVA). p-HSP20 NP, p-HSP20 nanoplex.
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    Endosomolytic nanoplex delivery system enhances the delivery of p-HSP20 and inhibition of contraction. Rings of rat aorta were suspended in a FluoroPlex Tissue Bath Fluorometry System that can measure contraction and intracellular calcium concentration simultaneously. Rings were untreated (control), treated with different doses of the p-HSP20 peptide alone (100, 500, and 1000 μM), or peptide-nanoplex formulations (100, 200, and 500 μM), and inhibition of contraction and calcium concentration were measured. (A) Representative tracing showing contraction with PE and inhibition of contraction with p-HSP20 NP. (B) Cumulative data demonstrating enhanced inhibition of contraction with p-HSP20 or p-HSP20 NP. (C) Representative tracing showing inhibition of contraction and intracellular calcium concentration with 500 μM p-HSP20 NP (500 μM polyplex). (D) Cumulative data showing percent inhibition of contraction (force) and intracellular calcium concentration ([Ca2+]i). A fivefold increase in peptide mediated bioactivity was observed when delivered through the endosomolytic NP formulation compared to peptide alone without any change in the [Ca2+]i. *p<0.05, **p<0.001, ****p<0.00001, n = 4–6 (one-way ANOVA). p-HSP20 NP, p-HSP20 nanoplex.

    Journal: Tissue Engineering. Part A

    Article Title: Nanotechnology Enabled Modulation of Signaling Pathways Affects Physiologic Responses in Intact Vascular Tissue

    doi: 10.1089/ten.tea.2018.0169

    Figure Lengend Snippet: Endosomolytic nanoplex delivery system enhances the delivery of p-HSP20 and inhibition of contraction. Rings of rat aorta were suspended in a FluoroPlex Tissue Bath Fluorometry System that can measure contraction and intracellular calcium concentration simultaneously. Rings were untreated (control), treated with different doses of the p-HSP20 peptide alone (100, 500, and 1000 μM), or peptide-nanoplex formulations (100, 200, and 500 μM), and inhibition of contraction and calcium concentration were measured. (A) Representative tracing showing contraction with PE and inhibition of contraction with p-HSP20 NP. (B) Cumulative data demonstrating enhanced inhibition of contraction with p-HSP20 or p-HSP20 NP. (C) Representative tracing showing inhibition of contraction and intracellular calcium concentration with 500 μM p-HSP20 NP (500 μM polyplex). (D) Cumulative data showing percent inhibition of contraction (force) and intracellular calcium concentration ([Ca2+]i). A fivefold increase in peptide mediated bioactivity was observed when delivered through the endosomolytic NP formulation compared to peptide alone without any change in the [Ca2+]i. *p<0.05, **p<0.001, ****p<0.00001, n = 4–6 (one-way ANOVA). p-HSP20 NP, p-HSP20 nanoplex.

    Article Snippet: Rings of rat aorta were suspended on hooks in a FluoroPlex Tissue Bath Fluorometry System (IonOptix LLC, Milton, MA and Radnoti Glass Technology, Inc., Monrovia, CA), which enables fluorescence ion recording in parallel with force measurement.

    Techniques: Inhibition, Concentration Assay